Oocytes, eggs and blastomeres of the embryo are special cells that undergo rapid changes in structure and function at developmental transitions. These changes are frequently regulated by cytoplasmic signaling events, particularly at the developmental transition of fertilization, because the genome is largely inactivated at this time. Protein kinase C (PKC) is a signaling agent that acts after the sperm‐induced rise in calcium and has a central role in the remodeling of the structure of the egg into the zygote in many (...) species. PKC also acts during other developmental transitions. This kinase serves as a chronometer, which can choreograph the cell's remodeling events in both space and time. Several technical advancements discussed in this review have permitted a better understanding of the actions of PKC. (shrink)

In this article, we first offer a model of design knowledge types and their interrelationships in value sensitive design. Then we demonstrate that value sensitive design is a formative framework, which provides a shaping influence on practice, enables creative appropriation, and supports theory and method development.

Drawing on ten years of research on the unpublished Wittgenstein papers, Stern investigates what motivated Wittgenstein's philosophical writing and casts new light on the Tractatus and Philosophical Investigations. The book is an exposition of Wittgenstein's early conception of the nature of representation and how his later revision and criticism of that work led to a radically different way of looking at mind and language. It also explains how the unpublished manuscripts and typescripts were put together and why they often provide (...) better evidence of the development of his ideas than can be found in his published writing. In doing so, the book traces the development of a number of central themes in Wittgenstein's philosophy, including his conception of philosophical method, the picture theory of meaning, the limits of language, the application of language to experience, his treatment of private language, and what he called the "flow of life." Arguing that Wittgenstein's views are often much more simple (and more radical) than we have been led to believe, Wittgenstein on Mind and Language provides an overview of the development of Wittgenstein's philosophy and brings to light aspects of his philosophy that have been almost universally neglected. (shrink)

Human Dignity in Contemporary Ethics develops a holistic and relevant understanding of human dignity for ethics today. Whilst critics of the concept of human dignity call for its dismissal, and many of its defenders rehearse the same old arguments, this book offers an alternative set of methodological assumptions on which to base a revitalized and practical understanding of human dignity, which at the same time overcomes the challenges that the concept currently faces. The Component Dimensions of Human Dignity model enables (...) human dignity to serve both as a descriptive category that explains moral choices, and as a normative criterion that helps to evaluate moral behaviour. A consideration of two cases--violent crime and physician-assisted suicide--demonstrates how the model offers a way to avoid the pitfalls of both moralism and moral relativism, while still leaving space for relativity in ethics. By using an approach that should be acceptable to both religious and secular perspectives alike, this book offers a unique way out of the 'dignity talk' that currently plagues ethics. (shrink)

Semiotic objections to markets urge us not to place a good on the market because of the message that doing so would send. Brennan and Jaworski reject them on the grounds that either the contingent semiotics of a market can be changed or the weakness of semiotic reasons allows them to be ignored. The scope of their argument neglects the impure semiotic objections that claim that the message a market sends causes, constitutes, or involves a nonsemiotic wrong. These are the (...) most compelling class of semiotic objections and are the kind actually advanced in the literature. Rather than focusing on the necessity or contingency of a market's semiotics, we should instead attend to a semiotic objection's most important feature: its purity or impurity. (shrink)

Examining the significance of Kant's account of "rational faith," this study argues that he profoundly revises his account of the human will and the moral philosophy of it in his later religious writings.

Philosophical analysis of ecological theories has lagged behind the study of evolutionary theory. The semantic conception of scientific theories, which has been employed successfully in the analysis of evolutionary theory, is adopted here to analyse ecological theory. Two general problems in ecology are discussed. One arises from the continued use of covering law models in ecology, and the other concerns the applicability of ecological theory in conservation biology. The semantic conception of ecological theories is used to resolve these problems.

The challenge to decolonise academic disciplines has been pertinent for many decades, but it has recently come to a new level of prominence, with vigorous discussion of what responding to this challenge might entail. This article explores what it might mean as an ethical challenge in the discipline of New Testament studies, using examples to illustrate two key (and related) tasks: the ‘parochialisation’ of European approaches to the discipline, and the paying of attention to perspectives from elsewhere in the world. (...) After a brief introduction to the decolonial challenge, there follows a brief survey of changing perspectives on the tasks of biblical studies, beginning with Johann Phillip Gabler's influential lecture from 1787, then C.H. Dodd's 1936 inaugural lecture, through to the more recent assessments of Markus Bockmuehl and Martin Hengel. This is followed by a survey of works of New Testament Introduction, moving from the classic work of Werner Georg Kümmel to the very recent Asian Introduction to the New Testament, edited by Johnson Thomaskutty. Finally, in light of these surveys, this article offers some reflections on decolonisation and the future(s) of New Testament studies. These reflections may suggest both parallels for the discipline of Christian ethics, and implications for the nature of the relationship between biblical studies and Christian ethics. (shrink)

Volume 20, Issue 8, August 2020, Page 96-98.

This paper uses a semiotic, performative theory of language and post-colonial theory to argue that nursing's representations of ‘multiculturalism’ need to be grounded in a theory of whiteness, an historicized understanding of how ethnic/cultural differences come to be represented in the ways they are and informed by Foucault's notions of power/knowledge. Using nursing education and ‘cultural compentency’ as examples, the paper draws on a range of literatures to suggest more critical and politically productive ways of approaching difference from within nursing's (...) largely white interpretive framework. (shrink)

This chapter contains section titled: Introduction: Baker on the Private Language Argument Strawson's and Malcolms Interpretations of the Beetle Story Pitcher's, Cook's, and Donagan's Interpretations of the Beetle Story Cohen's Repudiation of the Beetle Story Hacker's and Baker's Interpretations of the Beetle Story.

Alexander Bogdanov’s first work of philosophy, Basic Elements of the Historical View of Nature, was fundamentally influenced by Friedrich Engels. As a Marxist philosopher seeking to elaborate a comprehensive, systematic, and scientific worldview appropriate for worker–students, Bogdanov found inspiration in Engels’s Anti-Dühring, which provided him with his monist conception of being and his ‘historical view of nature’ and pointed him toward three critical elements of his work: the monism of motion, Spinoza’s naturalist and determinist system, and Charles Darwin’s conception of (...) natural selection. Bogdanov’s overall goal was to demonstrate that in nature, life, the psyche, and society there is no such thing as self-generated motion; all change occurs because of external action. For the individual and for society this means that existence determines consciousness, and societies evolve as a result of their struggle for existence, which is manifested first and foremost in labor. (shrink)

The alliance of discursivity with neurosis on the one hand, and an exploration of new conditions of discourse on the other, conditions now self consciously denoted as 'West', gives notice of a certain disillusionment I feel with my culturally received, monotheistic valourization of the power of 'word-ing', and my sense that the problem is not discourse per se, but the way my understanding of it is, or has been, too stuck within its own cultural self enclosure, within the compound of (...) its own cultural grammar, one might say. In taking up these issues within the context of a conference convened to consider "Fragmentation and the Desire for Order/Unity" play off each other relationally, or symbiotically but how so inevitably and incidentally in the West that play-off has a neurotic tail-chasing character that is inspired precisely by Desire. My remarks, therefore, about the possibilities of new conditions of discourse for the West, turn most profoundly on a problematizing of Desire itself. (shrink)

Wittgenstein's principal works, the Tractatus Logico‐Philosophicus and Philosophical Investigations, are each written in such strikingly unconventional ways that it takes considerable effort to translate them into conventional philosophical writing. The most important aspect of Wittgenstein's style for an understanding of his philosophy is his use of multiple voices, and the way he forces his reader to engage with those voices in order to understand him. This chapter provides an outline of the leading macro‐level answers to the question which of Wittgenstein's (...) writings set out his philosophy, and which set out views he rejected. Wittgenstein's method of composition, revision, and rearrangement, leads from the remarks written down in his wartime notebooks, to a manuscript containing several stages of construction of the Prototractatus, and from there to the polished typescript of the Tractatus. The chapter illustrates how to interpret Wittgenstein's remarks without taking a position on questions about texts and style, voice and authorship. (shrink)

The "standard account" of Wittgenstein’s relations with the Vienna Circle is that the early Wittgenstein was a principal source and inspiration for the Circle’s positivistic and scientific philosophy, while the later Wittgenstein was deeply opposed to the logical empiricist project of articulating a "scientific conception of the world." However, this telegraphic summary is at best only half-true and at worst deeply misleading. For it prevents us appreciating the fluidity and protean character of their philosophical dialogue. In retrospectively attributing clear-cut positions (...) to Wittgenstein and his interlocutors, it is very easy to read back our current understanding of familiar distinctions into a time when those terms were used in a much more open-ended way. The paper aims to to provide a broader perspective on this debate, starting from the protagonists’ understanding of their respective positions. Too often, the programmatic statements about the nature of their work that are repeated in manifestoes, introductions, and elementary textbooks have occupied center stage in the subsequent secondary literature. Consequently, I focus on a detailed examination of a turning point in their relationship. That turning point is Wittgenstein's charge, in the summer of 1932, that a recently published paper of Carnap's, "Physicalistic Language as the Universal Language of Science", made such extensive and unacknowledged use of Wittgenstein's own ideas that Wittgenstein would, as he put it in a letter to Schlick, "soon be in a situation where my own work shall be considered merely as a reheated version or plagiarism of Carnap’s." While the leading parties in this dispute shared a basic commitment to the primacy of physicalistic language, and the view that all significant languages are translatable, there was a remarkable lack of mutual understanding between them, and deep disagreement about the nature of the doctrines they disputed. Three quarters of a century later, we are so much more conscious of the differences that separated them than the points on which they agreed that it takes an effort of historical reconstruction to appreciate why Wittgenstein once feared that his own work would be regarded as a pale shadow of Carnap’s. (shrink)

Discussion of Alexander Bogdanov as a Marxist revisionist has largely centred on his philosophy of being and cognition and on Plekhanov’s and Lenin’s accusation that Bogdanov was an idealist renegade from Marxism. However, the real issue of revisionism at the time was not materialism but determinism: the question of whether socialism would appear by the working of the objective laws of nature or the subjective will of human beings. Bogdanov did indeed revise Marxism, but he did so in order to (...) defend it as a natural science. He conceived of society as a form of life subject to biological laws of nature: the need to assimilate energy from the environment and the need to adapt to the environment in the struggle to survive. He reinterpreted the key elements of scientific socialism – the idea that existence determines consciousness and the labour theory of value – in terms of this worldview. (shrink)

Identity, Morality, and Threat offers a critical examination of the social psychological processes that generate outgroup devaluation and ingroup glorification as the source of conflict. Daniel Rothbart and Karyna Korostelina bring together essays analyzing the causal relationship between escalating violence and opposing images of the Self and Other.

Wittgenstein's 'middle period' is often seen as a transitional phase connecting his better-known early and later philosophies. The fifteen essays in this volume focus both on the distinctive character of his teaching and writing in the 1930s, and on its pivotal importance for an understanding of his philosophy as a whole. They offer wide-ranging perspectives on the central issue of how best to identify changes and continuities in his philosophy during those years, as well as on particular topics in the (...) philosophy of mind, religion, ethics, aesthetics, and the philosophy of mathematics. The volume will be valuable for all who are interested in this formative period of Wittgenstein's development. (shrink)

Examines the ethical dilemmas created by contemporary biomedical advances, describing the techniques, applications, and ethical, legal, moral, and social ramifications of such developments as artificial insemination, cloning, prenatal screening, redesigne.

This paper examines a number of river images which have been attributed to Heraclitus, the ways they are used by Plato and Wittgenstein, and the connection between these uses of imagery and the metaphilosophical issues about the nature and limits of philosophy which they lead to. After indicating some of the connections between Heraclitus’, Plato’s and Wittgenstein’s use of river images, I give a preliminary reading of three crucial fragments from the Heraclitean corpus, associating each with a different river image. (...) Each of these images implies an overall conception of the nature of change and continuity and of the relationship between language and world. I then turn to the use of these images by Plato and Wittgenstein, and explore the relationship between their uses of river imagery and their conceptions of philosophy. To put it slightly differently, this paper is about Plato’s and Wittgenstein’s use of certain Heraclitean ideas. (shrink)

Otto Weininger was one of the most controversial and widely read authors of fin-de-siècle Vienna. He was both condemned for his misogyny, self-hatred, anti-semitism and homophobia, as well as praised for his uncompromising and outspoken approach to gender and morality. For Wittgenstein Weininger was a 'remarkable genius'. He repeatedly recommended Weininger's Sex and Character to friends and students and included the author on a short list of figures who had influenced him. The purpose of this new collection of essays is (...) to explore the various ways in which Wittgenstein absorbed and responded to Weininger's ideas. Written by an international team of experts on Wittgenstein and Weininger, the volume is especially timely in the light of recent translations of Weininger's work and will appeal to anyone interested in the history of 20th century philosophy, and the literary and cultural history of fin-de-siècle Vienna. (shrink)

With a challenging title, based on an anecdote about a dialogue between a scientist/philosopher and a lady on the structure of the universe, David Kirchhoffer proposes that the insight that human beings are the world (rather than merely live in the world) should be our starting point for reflections on theological anthropology. Relationality thus being the key-word for an up-to-date theological anthropology, this chapter discusses the main challenges that such an anthropology faces: first, anthropocentrism (challenged by the ecological crises, (...) the debate on who counts as a person and technology); second, historicity (as introduced by social-constructivism and as taken more seriously in the Christian tradition in recent decades); third, vulnerability (as a morally neutral consequence of our interdependency); and finally, language (as a means to engage with diverse discourses ranging from art through to philosophy,business and cognitive neuropsychology). More than claiming to know the solutions for these different challenges, Kirchhoffer rather encourages theologians to further reflect on them and the way they are discussed in theological and other discourses with a necessary (self-)critical epistemological suspicion. For only in this way will we arrive at a relevant theological discourse on what human beings are, and be a legitimate dialogue partner for other discourses. (shrink)

I argue that the numbering system of the Tractatus lets us see how it was constructed, in two closely related senses of that term. First, it tells us a great deal about the genesis of the book, for the numbering system was used to assemble and rearrange a series of drafts, as recorded in MS 104. Second, it helps us understand the structure of the published book, as cryptically summarized in the opening footnote. I also discuss an unpublished letter from (...) Anscombe to von Wright from 1948 which contains the very first sketch of a tree-structured reading, and what I believe is Stenius’s response to Anscombe’s proposal. The paper critically evaluates previous work on tree-structured readings and contends that we need to read the Tractatus in both the number order used in the published book and the tree order that Wittgenstein used to draft it. It also considers some of the main ways of turning this complex branching structure into a linear, printed text, and so serves as an introduction to the three tree-structured editions of the Tractatus that accompany this paper (the German text, and the translations by Ogden/Ramsey and Pears & McGuinness). (shrink)

This book makes an important contribution to ongoing efforts in the fields of medical law and bioethics to answer the challenges posed by the limitations of the principle of respect for autonomy, especially as these pertain to human research ethics. The principle of respect for autonomy seems to have become firmly embedded in human research ethics since its inclusion in the 1947 Nuremberg Code, which was a response to atrocities committed by Nazi doctors. Nonetheless, there is an increasing awareness of (...) the limitations of the principle of respect for autonomy and the underlying conceptualisations of human autonomy. (shrink)

Between 1899 and 1906, Alexander Bogdanov developed a scientific philosophy intended to substantiate the basic principle of historical materialism—the idea that existence determines consciousness—in terms of the most advanced science and empiricist epistemology/ontology of his day. At the same time, however, he strove ‘to answer the broad needs of our workers for an overall worldview’, and in the process of doing so he elaborated a complete philosophical system and a holistic worldview. Although his intention was to serve the proletariat and (...) advance socialist revolution, Bogdanov also provided the sort of integral vision of the interconnectedness of the individual, society, and the cosmos that the Russian intelligentsia had traditionally pursued. Bogdanov adopted a number of the principles of nineteenth-century German and Russian idealism, including the concept of the unity of the subject and the object and the ideas that the laws of thought are the same as the laws of being, that there is no qualitative difference between humans and nature, and that humanity is central in the progressive development of the cosmos. Bogdanov, however, provided a materialist mirror image of the idealist worldview. While Russian idealists celebrated spirituality, individual personhood, freedom, and religion, Bogdanov advocated materialism, collectivism, determinism, and naturalism. (shrink)

Whose values should count – those of patients or the general public – when adopting the quality-adjusted life year framework for healthcare decision making is a long-standing debate. Specific disciplines, such as economics, are not wedded to a particular side of the debate, and arguments for and against the use of patient values have been discussed at length in the literature. In 2012, Sinclair proposed an approach, grounded within patient preference theory, which sought to avoid a perceived unfair discrimination against (...) people with disabilities when using values from the general public. Key assumptions about general public values that beget this line of thinking were that ‘disabled states always tally with lower quality of life’, and the use of standardised instruments means that ‘you are forced into a fixed view of disability as a lower value state’. Drawing on recent contributions to the health economics literature, we contend that such assumptions are not inherent to the incorporation of general public values for the estimation of QALYs. In practice, whether health states of people with disabilities are of ‘lower value’ is, to some extent, a reflection of the health state descriptions that members of the public are asked to value. (shrink)